POSTERS

Cancer is a dynamic disease which, over time, may result in nonuniform distribution of distinct tumor cell subpopulations at different sites (spatial heterogeneity) or an increase in molecularly diverse cells (temporal heterogeneity). Here we report the exploratory objectives of tumor burden and CTC analysis using QTBI and VERSA in men with mCRPC to bone treated with enzalutamide.

18F-NaF positron emission tomography/computed tomography (PET/CT) scan is an approved tool to detect and evaluate osteoblastic metastases that is more sensitive and specific than conventional bone scintigraphy. Here we assess the proportion of men treated with enzalutamide with responding lesions by 18F-NaF PET/CT scan at the time of prostate-specific antigen (PSA), standard radiographic, or clinical progression.

The purpose of this investigation was to understand and quantify the inter-lesion heterogeneity in treatment response seen on 68Ga-DOTATATE PET/CT imaging over the course of Lutathera therapy